Table 3.
Level of EPA (g/100 g fatty acids) in RBC, plasma, liver, spleen, retina and brain in rats.
| Experimental Groups | ||||||
|---|---|---|---|---|---|---|
| FO | FO + O | Vanil + O | Acetyl + O | MAG + O | ||
| Mean ± SD | Mean ± SD | Mean ± SD | Mean ± SD | Mean ± SD | ||
| RBC | Day 3 | 0.2 ± 0.1 | 0.3 ± 0.0 | 0.3 ± 0.1 | 0.3 ± 0.0 | 0.3 ± 0.2 |
| Day 21 | 3.3 ± 0.6 * | 2.6 ± 0.4 | 5.5 ± 1.9 * | 4.6 ± 1.6 ** | 5.6 ± 0.6 ** | |
| Plasma | Day 3 | 0.5 ± 0.1 | 0.6 ± 0.1 | 0.6 ± 0.1 | 0.7 ± 0.1 | 0.6 ± 0.1 |
| Day 21 | 4.5 ± 0.9 | 4.3 ± 0.9 | 8.5 ± 1.1 ** | 7.0 ± 1.5 ** | 8.5 ± 1.6 ** | |
| Liver | 3.7 ± 0.74 | 3.1 ± 0.92 | 6.5 ± 1.57 ** | 5.2 ± 1.72 ** | 7.9 ± 2.14 ** | |
| Spleen | 1.9 ± 0.57 * | 1.1 ± 0.36 | 2.1 ± 0.8 * | 2.1 ± 0.62 * | 2.6 ± 0.59 ** | |
| Retina | 0.3 ± 0.06 * | 0.2 ± 0.05 | 0.4 ± 0.03 ** | 0.4 ± 0.08 ** | 0.45 ± 0.04 ** | |
| Brain | 0.05 ± 0.01 ** | 0.1 ± 0.03 | 0.2 ± 0.02 ** | 0.1 ± 0.05 | 0.2 ± 0.03 ** | |
*, **, *** indicate P < 0.05, 0.01 and 0.001, respectively; FO + O = Fish oil + Orlistat, Vanil + O = MAG Vanillin Acetal + Orlistat, Acetyl + O = Diacetylated MAG + Orlistat, MAG + O = MAG + Orlistat; Values are medians ± robust SD (n = 6). For statistics, data for groups fed fish oil diet or diets supplemented with MAG and MAG derivatives + Orlistat have been compared to the group receiving fish oil + Orlistat.