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. 2012 Nov 2;10(11):2435–2447. doi: 10.3390/md10112435

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© 2012 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

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Desensitization of TRPA1-HEK-293 as a result of 5-min pre-incubation of cells with 1–6. These compounds prevented the elevation of [Ca²⁺]_i induced by AITC 100 μM in a concentration-dependent manner. Responses were measured as peak increases in fluorescence and expressed as percentages of the uninhibited response.