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. 2012 Oct 26;13(11):13881–13893. doi: 10.3390/ijms131113881

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© 2012 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.

This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0).

PMC Copyright notice

Effect of FOXQ1 knockdown on the cell cycle. (a) Cell cycle analysis showed downregulation of FOXQ1 expression in SKOV3 cells leaded to a decreased population of cells in the S-phase, whereas an increased population of cells in the G0/G1 phase. (P8, P7, and P9 represent G0/G1, S, and G2/M phases, respectively). (b) A panel of cell cycle-related proteins were analyzed using western blots. cyclin D1, CDK4, and cyclin E were downregulated after FOXQ1 knockdown, whereas p21^Cip1 and p27^Kip1 were upregulated compared with the control groups. (c) Apoptosis was detected by measuring the activities of caspase 3/7 using a commercial kit at both 36 h and 48 h after infection of SKOV3 cells with shFOXQ1-3 or control shRNA lentivirus. **p < 0.01.