Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
The canonical and NHEJ-alternative pathways. (A) The canonical NHEJ pathway, involving KU and XRCC4, can seal double-strand ends, even distal and non-fully complementary ends, in a conservative fashion; (B) In the alternative pathway, the main event is extended deletion at the junction, generally associated with the use of internal microhomologies distant from the ends. And XRCC1 and DNA ligase-III are used for strand ends ligation.
