Table 2.
Summary of anti-leukemic effects of phenolic constituents of honey in various cell lines.
| Phenolic compound | Cell line | Mechanism of action (s) |
|---|---|---|
| Quercetin | HL-60 | Cell cycle arrest, inhibition of growth and proliferation |
| K562 | Induction of apoptosis and differentiation | |
| U937 | Induction of apoptosis cell cycle arrest | |
| Kaempferol | HL-60 | Cell cycle arrest and growth inhibition |
| Galangin | HL-60 | Antiproliferation and induction of apoptosis |
| Apigenin | HL-60 | Induction of apoptosis |
| THP | Induction of apoptosis | |
| U937 | Induction of apoptosis | |
| Acacetin | Jurkat cells | Growth inhibition and induction of apoptosis |
| Fisetin, myricetin and wogonin | HL-60 | Induction of apoptosis |
| CAPE | HL-60 | Growth inhibition and induction of apoptosis |
| U937 | Induction of apoptosis | |
| Chrysin | U937 | Induction of apoptosis |
| YCUB series | Growth inhibition and induction of apoptosis | |
| Luteolin | HL-60 | Growth inhibition and induction of apoptosis |
| Hesperidin | NALM-6 | Growth inhibition and induction of apoptosis |
| Dicaffeoylquinic acids and caffeoylquinic acid derivatives | HL-60 | Growth inhibition, induction of apoptosis and Differentiation |
| Genkwanin | K562 | Cytotoxicity |
| Rosmarinic acid and derivatives | K562 | Growth inhibition and induction of apoptosis |
| Other phenolic acids | HL-60 | Growth inhibition and induction of apoptosis |