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. 2012 Oct 26;4(11):2471–2484. doi: 10.3390/v4112471

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© 2012 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

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NPC1’s domain C converts NPC1L1 into a highly effective filovirus receptor. (a-b) Infection of CT43 cells expressing NPC1-flag, NPC1L1-flag, or the indicated flag-tagged NPC1L1-NPC1 chimeras by VSV pseudotypes bearing filovirus glycoproteins (a) or authentic filoviruses. nd, not determined. (b). Asterisks indicate data points at or below the limit of detection. (c) Expression of NPC1L1-flag and the indicated flag-tagged NPC1L1-NPC1 chimeras in CT43 cells was detected by immunoblotting with an anti-flag antibody. (d) Co-immunoprecipitation of NPC1L1-NPC1 chimeras by EBOV GP was performed as described in Fig. 1d.