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. 2012 Oct 26;4(11):2471–2484. doi: 10.3390/v4112471

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© 2012 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

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N-terminal sequences from NPC1 domain C render NPC1L1 competent to mediate filovirus entry. (a) Alignment of domain C amino acid sequences from human NPC1 and NPC1L1. Sequence differences are shaded in gray. Sequences exchanged between domains are outlined in red and green. Cysteines are highlighted in yellow. (b) Infection of CT43 cells expressing NPC1L1-flag, NPC1L1-NPC1(C)-flag, or NPC1L1-NPC1 intra-domain C chimeras by VSV pseudotypes bearing filovirus glycoproteins. Asterisks indicate data points at or below the limit of detection. (c) Expression of the indicated flag-tagged proteins in CT43 cells was detected by immunoblotting with an anti-flag antibody. Samples in Figs. 3b and 4c were resolved on the same SDS-polyacrylamide gel.