Table 2.
Different Chemical Modifications and Survival in Ebola virus Mouse Lethal Challenge Model
| Viral Target | PMO (0.5 mg/mouse)* | PPMO (0.05 mg/mouse) | PMOplus (0.05 mg/mouse) |
|---|---|---|---|
| leader | 10.0 ± 14.1 (2) | (N.T.) | (N.T.) |
| NP | 20.0± 00.0 (2) | (N.T.) | (N.T.) |
| VP35 | 79.1 ± 30.2 (11)** | 95.7 ± 7.9 (7) | 68.9 ± 23.9 (9) |
| VP40 | 45.0 ±7.1 (2) | (N.T.) | (N.T.) |
| GP | 15.0 ± 12.9 (4) | 70.0 ± 00.0 (1) | (N.T.) |
| VP30 | 40.0 ± 00.0 (2) | (N.T.) | (N.T.) |
| VP24 | 68.8 ± 28.5 (9)** | 63.1 ± 36.1 (61) | 37.1 ± 29.6 (24) |
| L | 35.0 ± 28.8 (4) | 72.5 ± 16.4 (8) | 8.3 ± 16.0 (6) |
| Control | 6.4 ± 8.5 (19) | 2.6 ± 4.6 (8) | 10.0 ± 22.4 (7) |
| Scramble Control | 7.5 ± 11.6 (20) | 24.3 ± 38.1 (15) | 26.7 ± 25.2 (3) |
* Values represent the mean percent survival ± standard deviation and number of treatment groups in parenthesis with 10 mice per group.
** Indicates significantly different from control and scramble control, p<0.05 Tukey’s Multiple Comparison Test.
N.T. Not tested.