Table 4.
Chemistry Comparison in Ebola virus Nonhuman Primate Lethal Challenge Model.
| Target | PMO | PPMO | PMOplus | |||
|---|---|---|---|---|---|---|
| Dose (mg/kg) | Percent Survival* | Dose (mg/kg) | Percent Survival | Dose (mg/kg) | Percent Survival | |
| VP35 | 300 | 00 (0/4) | - | - | - | - |
| (AVI-7539)** | ||||||
| VP35+VP24 | - | - | - | - | 40 | 61 (8/13) |
| (AVI-6002)** | ||||||
| VP35 + VP24 + L | 350-450*** | 25 (3/12) | 18 (MTD) | 00 (0/3) | - | - |
| (AVI-7539, AVI-7537, NG-06-0648)** | ||||||
| Control | - | 00 (0/4) | - | 00 (0/1) | - | 00 (0/2) |
* Percent survival, these numbers of survivors over the total number treated are indicated in parenthesis. Long-term survival was determined by those animals that survived to 28 days post infection.
** The numbers refer to the PMOplus but the sequences are the same as for the PMO and PPMO
*** Two studies are combined in which the dose ranged from 350 to 450 mg/kg/