Table 5.

Incidence of solicited systemic events after the first and second vaccination.

	Adjuvanted HAI-05						Unadjuvanted HAI-05		Placebo
	15 µg N = 18		45 µg N = 20		90 µg N = 20		90 µg N = 20		N = 22
Vaccinationn (%) a	Dose 1 b	Dose 2 b	Dose 1	Dose 2	Dose 1	Dose 2	Dose 1	Dose 2	Dose 1	Dose 2
Fever	0	0	0	0	0	0	0	1 (5.0)	1 (4.5)	0
Tiredness	4 (22.2)	4 (22.2)	4 (20.0)	2 (10.0)	5 (25.0)	1 (5.0)	3 (15.0)	1 (5.0)	2 (9.1)	1 (4.5)
Chills	2 (11.1)	1 (5.6)	1 (5.0)	0	1 (5.0)	0	1 (5.0)	0	2 (9.1)	1 (4.5)
Malaise-Feeling Discomfort	1 (5.6)	2 (11.1)	0	0	3 (15.0)	4 (20.0)	1 (5.0)	0	3 (13.6)	1 (4.5)
Joint Aches	2 (11.1)	2 (11.1)	1 (5.0)	1 (5.0)	1 (5.0)	1 (5.0)	2 (10.0)	0	1 (4.5)	1 (4.5)
Muscle Aches	4 (22.2)	4 (22.2)	3 (15.0)	2 (10.0)	4 (20.0)	3 (15.0)	2 (10.0)	2 (10.0)	2 (9.1)	2 (9.1)
Headache	4 (22.2)	4 (22.2)	4 (20.0)	2 (10.0)	7 (35.0)	6 (30.0)	4 (20.0)	4 (20.0)	4 (18.2)	0

^a: Number (%) of subjects reporting symptom. Each subject was counted only once.

^b: Between Days 1 and 8.

^c: Between Days 22 and 29.