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. 2012 Nov 7;4(11):1196–1222. doi: 10.3390/toxins4111196

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© 2012 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

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Representation of neutralizing and non-neutralizing antibodies against BoNT/A, and BoNT/B [106]. Neutralizing antibodies against BoNT/A <1> and B <2> affect neurotoxin heavy chain carboxyl terminal (Hcc), preventing its binding to presynaptic cells. Antibodies lacking neutralizing effects against BoNT/A <4> and BoNT/B <3> do not affect neurotoxin binding. According to somestudies, cross antibodies can recognize BoNT/A and BoNT/B <5,6>, but they do not affect neurotoxin binding [106]. A recent study reported neutralizing cross-reacting antibodies between neurotoxin serotypes <7> [107].