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. 2012 Aug 28;3(11):941–951. doi: 10.1021/cn3000857

Table 2. Names and IC50’s for Reduction of Aβ40/42 of Compounds Isolated from Black Cohosh Extract (1–9) and Chemical Derivatives of 1 (10–12).

    IC50 (nM)
compd no. compd name Aβ40 Aβ42
1 24-O-acetylhydroshengmanol (Δ-16,17)-enol ether-3-O-β-d-xylopyranoside, (24S) 6300 100
2 actein >50 000 >50 000
3 cimigenol-3-O-β-d-xylopyranoside >50 000 >50 000
4 cimigenol-3-O-α-l-arabinopyranoside >50 000 >50 000
5 24-O-acetylhydroshengmanol-3-O-β-d-xylopyranoside, (24S) 50 000 5600
6 24-epi-24-O-acetylhydroshengmanol (Δ-16,17)-enol ether-3-O-β-d-xylopyranoside, (24R) >50 000 1000
7 24-O-acetylhydroshengmanol-3-O-α-l-arabinopyranoside, (24S) >50 000 32 000
8 24-O-acetylhydroshengmanol (Δ-16,17)-enol ether-3-O-α-l-arabinopyranoside, (24S) 16 000 1000
9 24-O-acetylhydroshengmanol-3-O-β-d-xylopyranoside, (24R) 16 000 3000
10 hydroshengmanol (Δ-16,17)-enol ether, (24S) 20 000 6300
11 hydroshengmanol (Δ-16,17)-enol ether-3-O-β-d-xylopyranoside, (24S) 43 000 1200
12 24-O-acetylhydroshengmanol (Δ-16,17)-enol ether, (24S) >10 000 >10 000