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Irx6 can act as a transcriptional repressor or activator on sites found proximal to OFF bipolar cell markers. (A) Potential IBS found proximal to Vsx1, Tacr3 (Nk3r) and Rcvrn. Numbered boxes indicate exons. (B,C) Irx6 represses both Vsx1-luciferase (B) and Nk3r-luciferase and activates Rcvrn-luciferase (C) expression in HEK cells. Data are mean±s.e.m.
