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. 2012 Dec 1;139(23):4383–4394. doi: 10.1242/dev.083352

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© 2012. Published by The Company of Biologists Ltd

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Fig. 4. — Wnt5a^+/− in combination with Fz7^−/− enhances the short tail phenotype and in combination with Fz2^+/−;Fz7^−/− causes mid-gestational lethality. (A,B) The only anatomical phenotype evident in Fz7^−/− mice is a ~10% decrease in tail length and a small kink at the end of the tail. The scatter plot shows tail length divided by body length, measured from the nose to the base of the tail, at 4 weeks of age. Wnt5a^+/− mice show no tail phenotype, but Wn5a^+/− enhances the Fz7^−/− tail shortening phenotype. Error bars indicate s.e.m. (C) E9.5 littermates illustrate the lethal growth retardation in Fz2^+/−;Fz7^−/−;Wnt5a^+/− embryos. Fz2^+/−;Fz7^−/−;Wnt5a^+/+ and Fz2^+/+;Fz7^−/−;Wnt5a^+/+ embryos are unaffected at this age. Unstained specimens are shown. Scale bar: 1 mm.