Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Enzyme Specificity, Zinc Chelation and Cellular Cytotoxicity
| IC50 μM (FRET ASSAY)* | |||
|---|---|---|---|
| Enzyme | MSL-145815 | MBX 1553 | Hydroxamate |
| BoNT/A Lc | 7.2 | 26 | 7.33 |
| BoNT/B Lc | >100 | >100 | >100 |
| MMP-1 | >100 | >100 | >100 |
| MMP-2 | >100 | >100 | >100 |
| MMP-9 | >100 | >100 | >100 |
| Ba. Lethal Factor | 74 | >100 | >100 |
| Zinc chelation | No | No | No |
| HeLa cell cytotoxicity, CC50 (μM) | 19 | 3.6 | 4.4 |
IC50 values represent averages of two separate assays.
