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. Author manuscript; available in PMC: 2012 Nov 29.
Published in final edited form as: Science. 2010 Jul 29;329(5997):1337–1340. doi: 10.1126/science.1191184

Fig. 2.

Fig. 2

Functional interaction between Fritz and septins. (A) Control embryo withclosed blastopore. (B) Sibling embryo treated with 100 μM FCF. (C) Sibling treated with 200μM FCF. (D) Sibling injected with a low dose of Fritz MO. (E) Sibling Fritz morphant treated with 100μM FCF. (F) Sibling Fritz morphant treated with 200 μM FCF. (G) Quantification of blastopore closure (mean ± SEM; n = nine embryos per column). (H) Sept2-GFP concentrated at the cortex (red in h′) of cells engaged in CE. (I) Cortical sept2-GFP concentration was reduced in Fritz morphants. (J) Sept2-GFP localization was quantified as the ratio of cortical versus cytoplasmic pixel intensities. (K)Cortical/cytoplasmic Sept2-GFP ratio was reduced significantly in Fritz morphants; the ratio of coexpressed membrane-RFP is unchanged (mean ± SEM; n = 123 cells for control, 150 for morphant).