Table 1.

Presentation of participants

Participant	Age at PGTa	Age at interview	Manifest or latent AIP	Disease manifestation in patients and relatives
1. Alex	10–12	21	lAIP	First-degree relative with unspecific symptoms
2. Morgan	11	17	lAIP	First-degree relative with one AIP attack. Second-degree relative with chronic and unspecific complaints
3. Billie	14	19	mAIP	Unspecific symptoms, more or less chronic complaints. Admitted to hospital twice. First-degree relative with unspecific and frequent complaints in earlier years
4. Drew	5–7	17	mAIP	Three AIP attacks requiring hospitalisation
5. Taylor	17	21	lAIP	No symptomatic relatives in immediate family
6. Chris	12	17	lAIP	First-degree relative with unspecific and frequent complaints
7. Morgan	15	16	lAIP	First-degree relative with several AIP attacks requiring hospitalisation
8. Bobbie	11	19	mAIP	One serious AIP attack. First-degree relative with a few attacks treated at home
9. Cameron	17	21	lAIP	First-degree relative with one attack
10. Francis	15	17	lAIP	First-degree relative with both unspecific and frequent symptoms and attacks requiring medical treatment

Unspecific symptoms – Symptoms perceived by the participants: fatigue, muscle aches, headaches, dizziness, etc that were not in combination with otherwise unexplained episodes of stomach/back pain with a duration of >12 h

^aPGT predictive genetic test