Fig. 1.

Gelatinase activity is altered in patients with Sanfilippo disease. (a) Representative gelatine zymography in the serum of patients with MPS III (n = 5) and age- and sex-matched controls (n = 5, for each MPS III patient). (b) Quantitative analysis of gelatinolytic activity in serum of patients with MPS III and healthy controls using a computer-supported image analysis program. Each bar represents the mean ± SED from zymographies which were performed in triplicate for each patient. Statistical significance: (*) p < 0.05