Fig. 3.

Enzyme replacement therapy alters gelatinase activity in MPS VI. (a) Representative gelatine zymography in the serum of a patient with MPS VI before the initiation of treatment (0), as well as 1, 2, 3, 4, and 6 months after treatment. (b–c) Quantitative analysis of gelatinolytic activity using a computer-supported image analysis program. Each bar represents the mean ± SED from zymographies which were performed in triplicate and are presented as % of the gelatinolytic activity of age- and sex-matched controls (n = 10)