Table 1.
Saline | Nembutal (5 mg/kg) | MK-801 (0.05 mg/kg) | |
---|---|---|---|
56.5 | 51.9 | 57.3 | |
p = 6 × 10−5 | p = 0.12 | ||
Rat 9245 | 56.1 Hz | 50.5 Hz | 57.0 Hz |
p = 3 × 10−8 | p = 0.2 | ||
Rat 9244 | 56.7 Hz | 52.5 Hz | 58.0 Hz |
p = 0.002 | — | ||
Rat 9233 | 56.8 Hz | 52.7 Hz | 57.0 Hz |
p = 3 × 10−4 | p = 0.9 |
Values are peak gamma frequencies, calculated by averaging across trials and 500 ms trial phases for each session and then averaging across sessions. p values are the results of t test comparisons of peak gamma frequency between drug and saline conditions. Top row shows means and p values across rats, and the bottom rows show means and p values within rats, across session. As a result of poor behavior in rat 9244, data collection under treatment with MK-801 was successfully obtained in only one session, so a within-rat comparison could not be made. Gamma frequency was consistently slower after administration of the barbiturate Nembutal (sodium pentobarbital), but gamma frequency after the NMDA antagonist MK-801 was not different from the saline condition.