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. Author manuscript; available in PMC: 2012 Nov 29.
Published in final edited form as: J Nucl Med. 2012 Jul 31;53(9):1383–1391. doi: 10.2967/jnumed.112.105734

SCHEME 1.

SCHEME 1

(i) 1,1′ carbonyl diimidazole, H2O2, Li imidazole, KHSO4, CH2Cl2; 0°C to room temperature, 40 min. (ii) 1,1′ carbonyl diimidazole, MeOH, CH2Cl2, 2 h, 0°C to room temperature. (iii) 10% HClO4, tetrahydrofuran, 0°C to room temperature, 4 h. (iv) Pb (OAc)4, DCM, −20°C, 30 min. (v) n-BuLi, 7 Wittig salt, tetrahydrofuran, −78°C, 3 h. (vi) Tetrabutylammonium fluoride, tetrahydrofuran, 0° C to room temperature, 3 h. (vii) TsCl, Et3N, CH2Cl2, 0°C to room temperature, 6 h. (viii) Tetrabutylammonium fluoride, tetrahydrofuran, 0°C to room temperature, 3 h. (ix) LiOH, tetrahydrofuran; H2O, room temperature, 24 h.