Table 1. LpxA crystal structures in the Protein Data Bank.
Structure similarity is based on BLAST alignment using the RCSB PDB query interface over the given number of amino acids (Align). Only ligands larger than ten non-H atoms are listed. U21, uridine-5′-diphosphate-3-O-(R-3-hydroxydecanoyl)-N-acetyl-D-glucosamine; U20, uridine-5′-diphosphate-3-O-(R-3-hydroxymyristoyl)-N-acetyl-D-glucosamine; UD1, uridine-diphosphate-N-acetylglucosamine; SOG, 2-hydroxymethyl-6-octylsulfanyl-tetrahydropyran-3,4,5-triol; U22, uridine-5′-diphosphate-3-N-(R-3-hydroxylauroyl)-N-acetyl-D-glucosamine; S2N, S-[2-({N-[(2R)-2-hydroxy-4-{[(S)-hydroxy(methoxy)phosphoryl]oxy}-3,3-dimethylbutanoyl]-β-alanyl}amino)ethyl] (3R)-3-hydroxydodecanethioate.
| Type | Species | Identity (%) | Similarity (%) | Align | PDB entry | Resolution (Å) | Ligands |
|---|---|---|---|---|---|---|---|
| LpxA | E. coli | 52 | 70 | 260 | 2qiv | 1.85 | U21 |
| 2qia | 1.74 | U20 | |||||
| 2jf3 | 3.00 | UD1 | |||||
| 2jf2 | 1.80 | — | |||||
| 2aq9 | 1.80 | Pentadecapeptide | |||||
| 1lxa | 2.60 | — | |||||
| LpxA | H. pylori | 42 | 59 | 254 | 1j2z | 2.10 | SOG |
| LpxA | L. interrogans | 36 | 61 | 255 | 3i3x | 2.10 | U22 |
| 3i3a | 2.10 | S2N | |||||
| 3hsq | 2.10 | — | |||||
| LpxA | C. jejuni | 36 | 58 | 220 | 3r0s | 2.30 | — |