TABLE 1:

Dissociation constants of POS-1 and GLD-1 for variants of the glp-1 fragment.

Identifier	Sequence	POS-1 Kd,app (nM)	GLD-1 Kd,app (nM)
glp-1 WT	UUUUUCUUAUUCUAGACUAAUAUUGUAAGCU	19 ± 2	70 ± 10
∆GBM	UUUUUCUUAUUCUAGACCAAUAUUGUAAGCU	21 ± 1	2000
∆5′ PRE	UUUUUCUCCCUCUAGACUAAUAUUGUAAGCU	55 ± 4	33 ± 7
∆3′ PRE	UUUUUCUUAUUCUAGACUAACCCUGUAAGCU	53 ± 1	25 ± 3
∆5′ 3′ PRE	UUUUUCUCCCUCUAGACUAACCCUGUAAGCU	310 ± 20	20 ± 3

Reported K_d,app values are the mean ± one SD of three independent replicates.