FIGURE 7:

Summary of interactions between Ypt7 Rab, HOPS, and SNAREs. Together with the published literature, our data suggest that several subunits of the HOPS complex coordinate binding of multiple SNARE domains. Vps33 directly binds the Qa-, Qc-, and R-SNARE domains, while the N-terminal H_abc and PX domains of the Qa- and Qc-SNAREs are bound by other subunits within HOPS. Interactions of HOPS subunits Vps39 and Vps41 with the Rab Ypt7 have been demonstrated previously (Brett et al., 2008; Plemel et al., 2011).