Skip to main content
. 2012 Nov 29;8(11):e1003042. doi: 10.1371/journal.pgen.1003042

Figure 6. Co-Localization of huntingtin and RRas in STHdh Q111/Q111 Cells and Q175 Knock-In Mouse Model.

Figure 6

(A) Mouse STHdh Q111/Q111 cell labeled with antibodies to huntingtin (upper left), RRAS (middle) and DAPI were imaged by confocal microscopy (upper panels). Lower panel shows STHdh Q111/Q111 cell labeled with cortactin (lower left), RRAS (middle) and DAPI imaged by confocal microscopy. Merged images are shown (right panels). (B) Immunohistochemistry of HdhQ175 (Q175) and littermate control brain (WT) cortex and striatum stained with anti-RRAS and anti-huntingtin antibodies at 7-months of age. (C) Quantification of colocalization of RRAS with Htt. **p<0.01, ***p<.005, Student's t-test.