Figure 7. Levels of Active R-Ras Are Elevated in HD Models.

(A) STHdh cells overexpressing R-Ras were subjected to GST-RBD pull-downs to detect the amount of GTP-bound R-Ras (n = 2). (B) The R6/2 mouse model of HD has increased GTP-bound R-Ras in the striatum (n = 3). The arrowheads indicate a higher molecular mass band of unknown origin that is only present in the pull-down samples. *p<0.05, Student's t-test.