Table 2. Ingenuity Pathway Analysis (IPA) Enriched Functional Categoriesa and Canonical Pathways for Suppressors.
| Functional Category | p-valueb | Genes |
| Neurological Disease | 0.0000646 | GRIN2A, HIF1A, PDE1A, NR3C1, APP, LGALS9, IL18R1, HRH1, AR, NR2F6, LTBR, GRIN1, GRIN2B, PAH, APTX, HRH2, PSMB5, CASP3, P2RX4, PDE9A, BACE1, HCN1, PREP, GLRA1, PDE5A, PAFAH1B1, UFD1L |
| Genetic Disorder | 0.0000953 | HAMP, GRIN2A, CD4, LHCGR, PDE1A, NR3C1, APP, LHB, PPP3R2, HRH1, AR, LDLRAP1, GRIN1, GRIN2B, PAH, APTX, HRH2, CASP3, PDE9A, BACE1, IL19, PDE5A, NAGLU, NR3C2, BACE2, CYLD, UFD1L |
| DNA Replication, Recombination and repair | 0.0001370 | APTX, PDE9A, PDE1B, PDE5A, PDE1A, NR3C1, KIFC1 |
| Nucleic Acid Metabolism | 0.0001370 | PDE9A, PDEB1, PDE5A, FABP1, HIF1A, PDE1A, APP |
| Small Molecule Biochemistry | 0.0001370 | ENPEP, MAP3K14, GRIN1, GRIN2A, HAMP, GPR81, PDE9A, LHCGR, HIF1A, PDE1A, NR3C1, LHB, APP, HRH1, GAST, AR, PLA2G2D, FABP5, PDE1B, NAGLU, FABP1, PDE5A, NR3C2 |
| Protein Degradation | 0.0005570 | ENPEP, GRIN2A, PSMB5, CASP3, C9ORF3, CPA1, BACE1, PHEX, PREP, LGMN, DPEP3, CAPN2, BACE2, UFD1L |
| Protein Synthesis | 0.0005570 | ENPEP, GRIN2A, PSMB5, CASP3, C9ORF3, CPA1, BACE1, HIF1A, APP, PHEX, PREP, IL19, LGMN, DPEP3, CAPN2, EIF2AK2, BACE2, UFD1L |
| Infectious Disease | 0.0005570 | PPP3R2, HRH1, GRIN1, GRIN2B, HRH2, GRIN2A, AR, CASP3, CD4, PDE5A, LTBR, NR3C1 |
| Cancer | 0.0005570 | KIF23, GRIN2A, CUGBP1, CD4, LHCGR, MKI67, TP53RK, HRH1, CACNA1E, FABP1, IL1RAP, KIFC1, MAP3K14, PTPRE, HRH2, PSMB5, CASP3, HCN1, IL18BP, ATP5C1, GAST, NR3C2, CYLD, CREBL2, ENPEP, ILK, MSLN, HIF1A, LHB, NR3C1, PPP3R2, DMTF1, PLGLB2, AR, ZNF24, NR2F6, MICA, TMPRSS4, GRIN1, GRIN2B, MIPEP, C9ORF3, USP1, AIP, PPP1R3D, FABP5, NR4A1, PDE5A, EIF2AK2, PPP2R1B |
| Reproductive System Disease | 0.0005570 | GRIN2A, ILK, LHCGR, MKI67, HIF1A, LHB, NR3C1, HRH1, AR, CACNA1E, ZNF24, RAD51C, GRIN2B, GRIN1, HRH2, PTPRE, PSMB5, CASP3, C9ORF3, HCN1, ATP5C1, NR4A1, PDE5A, NR3C2, CYLD, EIF2AK2, PPP2R1B |
| Respiratory Disease | 0.0005890 | GRIN2B, GRIN1, PAH, HRH2, GRIN2A, CASP3, CD4, HIF1A, NR3C1, PPP3R2, HRH1, IL19, PDE5A, CYLD, LTBR |
| Gene Expression | 0.0005890 | MAP3K14, TPSD1, CD4, ILK, HIF1A, LGALS9, NR3C1, APP, MED14, DMTF1, GAST, AR, FABP5, NR4A1, NR3C2, LTBR, NR2F6, EIF2AK2, TNFSF13B |
| Nervous System Development and Function | 0.0006870 | GLRA2, GRIN1, GRIN2B, GRIN2A, CASP3, P2RX4, BACE1, HIF1A, APP, NR3C1, HRH1, CACNA1E, AR, GLRA1, PDE1B, PLCB3, HTR1F, NR3C2, LTBR, PAFAH1B1 |
| Cell Cycle | 0.0009920 | KIF23, CD4, ILK, MKI67, HIF1A, MLL5, APP, NR3C1, DMTF1, AR, PPP1R13B, FABP1, PPM1A, LDLRAP1, RAD51C, KIFC1, TNFSF13B, PSMB5, CASP3, DAXX, GAST, NR4A1, CAPN2, EIF2AK2, CYLD, PAFAH1B1, DIABLO, POLH |
| Cell Death | 0.0010500 | CREBL2, GRIN2A, CD4, ILK, LHCGR, DLX4, HIF1A, NR3C1, LGALS9, APP, AR, PPP1R13B, CYB5R3, FABP1, PPM1A, LTBR, RAD51C, MICA, KIFC1, TNFSF13B, GRIN2B, GRIN1, PTPRE, PSMB5, CASP3, P2RX4, BACE1, TNFSF18, DAXX, IL19, PPP1R3D, GAST, PDE1B, NR4A1, EIF2AK2, CYLD, PAFAH1B1, DIABLO, PPP2R1B, POLH |
| Behavior | 0.0014200 | GRIN2B, GRIN1, UCHL3, GRIN2A, CASP3, LHCGR, HCN1, BACE1, HIF1A, APP, NR3C1, GAST, AR, GLRA1, PDE1B, NR3C2, PAFAH1B1 |
| Cellular Development | 0.0017100 | CUGBP1, CASP3, CD4, PTP4A3, LHCGR, LGALS9, LHB, APP, AR, PPM1A, LDLRAP1, PAFAH1B1, RAD51C, NFSF13B |
| Reproductive System Development and Function | 0.0017100 | GRIN1, CUGBP1, AR, CASP3, LHCGR, EIF2AK2, RAD51C, PAFAH1B1, APP, NR3C1, LHB, ADAM21 |
| Inflammatory Response | 0.0021700 | GRIN2A, HAMP, CD4, LHCGR, HIF1A, MLL5, NR3C1, APP, LGALS9, IL18R1, PPP3R2, HRH1, APOBEC3F, LTBR, IL1RAP, TNFSF13B, HRH2, CASP3, AIP, IL18BP, IL19, PIK3AP1, CYLD, EIF2AK2, ADAM9 |
| Dermatological Diseases and Conditions | 0.0023700 | GRIN2B, GRIN1, GRIN2A, HRH2, CD4, HIF1A, APP, NR3C1, IL18BP, PPP3R2, HRH1, IL19, AR, NR4A1, PDE5A, EIF2AK2, POLH |
| Immunological Disease | 0.0023700 | GRIN2A, CD4, HGD, PDE1A, LGALS9, NR3C1, IL18R1, PPP3R2, HRH1, CPB1, AR, LTBR, IL1RAP, MICA, KIFC1, TNFSF13B, ACPP, GRIN2B, HRH2, PSMB5, MIPEP, PDE9A, C9ORF3, USP1, HDLBP, IL18BP, DAXX, IL19, ADAMTS6, GLRA1, PDE1B, NR4A1, PDE5A, PIK3AP1, EIF2AK2, DIABLO |
| Inflammatory Disease | 0.0023700 | GRIN2A, CD4, PDE1A, APP, NR3C1, IL18R1, PPP3R2, HRH1, CPB1, MICA, TNFSF13B, KIFC1, ACPP, HRH2, MIPEP, PDE9A, C9ORF3, HDLBP, USP1, IL18BP, DAXX, IL19, ADAMTS6, PDE1B, NR4A1, PDE5A, PIK3AP1, EIF2AK2 |
| Organ Morphology | 0.0031200 | UCHL3, MAP3K14, AR, CASP3, LHCGR, CYLD, LTBR, LHB, NR3C1, IL1RAP, APP, TNFSF13B |
| Organismal Injury and Abnormalities | 0.0031500 | GRIN2B, GRIN1, HRH2, HAMP, GRIN2A, CD4, HIF1A, NR3C1, APP, PPP3R2, HRH1, AR, FABP1, PDE5A, HTR1F, LTBR |
| Psychological Disorders | 0.0031900 | GRIN2B, GRIN1, PAH, GRIN2A, HRH2, PDE9A, BACE1, PDE1A, APP, NR3C1, PREP, HRH1, PDE5A, UFD1L |
a
The top 25 of 79 enriched functional categories are shown.
b
Benjamini-Hochberg adjusted p-values were back calculated from −log values given by IPA by using those values as exponents to −10 (i.e. −100.05).