Table 1. GWAS and validation of SNPs association data in two independent NPC cohorts.

				GWAS (N = 1,043)			Validation (N = 985)			Combined (N = 2,028)
SNP name	Gene	Chr.	MA†	MAF‡	P-value	OR(95% CI)	MAF	P-value	OR(95% CI)	P-value	OR (95% CI)
rs417162	HLA-A	6	C	0.26/0.37	1.13E-07	0.58(0.48–0.71)	0.26/0.35	3.75E-05	0.63(0.50–0.78)	1.05E-11	0.63(0.53–0.75)
rs2517713*	HLA-A	6	G	0.26/0.37	3.03E-07	0.57(0.46–0.71)	0.26/0.35	2.61E-05	0.62(0.50–0.78)	1.63E-11	0.60(0.52–0.70)
rs9260734*	HCG9	6	A	0.22/0.32	5.90E-07	0.57(0.45–0.71)	0.21/0.32	1.32E-05	0.59(0.47–0.75)	2.63E-11	0.59(0.50–0.69)
rs5009448*	HCG9	6	T	0.26/0.35	1.09E-05	0.63(0.51–0.77)	0.24/0.35	4.43E-07	0.56(0.45–0.70)	6.40E-11	0.61(0.53–0.71)
rs2267633	GABBR1	6	G	0.17/0.26	1.43E-06	0.58(0.47–0.73)	0.17/0.24	2.77E-04	0.63(0.49–0.81)	1.89E-09	0.61(0.52–0.72)
rs29230*	GABBR1	6	C	0.17/0.25	2.37E-05	0.60(0.47–0.76)	0.17/0.24	6.02E-04	0.65(0.50–0.83)	9.48E-09	0.61(0.52–0.72)

^*: Replication SNPs that not included in Affymetrix Genome-Wide SNP Array;

^†: MA, Minor allele;

^‡: MAF, Minor allele frequencies;