Table 2. Effect of Catalase activity on cardiac transcriptome at 40 days.

	N° of genes(1)	GO term enrichment(2)	Cluster 1 Enrichment(3)	Cluster 2 Enrichment(4)	JNK pathway enrichment(5)
Induced in Cat LOF versus GOF	187	Defense response	4/472p = 0.76	59/635p = 4.9 10−35	1/133p = 0.53
Repressed in Cat LOF versus GOF	521	Proteolysis	119/472p = 3.22 10−68	20/635p = 0.73	3/133p = 0.73

Overview of genes deregulated in 40 days old cardiac tubes between Catalase Loss of function (LOF) and Gain of Function (GOF). Enrichment p values were calculated using a test based on hypergeometric distribution.

⁽¹⁾Deregulated genes between Hand-GS/UAS>Ca-IR (Cat LOF) and Hand-GS/UAS>Catalase (Cat GOF) 40 days-old cardiac tubes dissected from flies fed with 100 µg/ml RU486 were determined using Rank Product software from normalized expression data (see Table S12).

⁽²⁾GO term enrichments were determined using the Flymine database (www.flymine.org) (see Table S13 for details).

⁽³⁾See Table 1 and Table S2 (repressed genes at 40 days compared to 10 days).

⁽⁴⁾See Table 1 and table S2 (induced genes at 40 days compared to 10 days).

⁽⁵⁾ [17], [18].