Table 2. Number of nonsynonymous and synonymous variants identified in APOA1 by apoA-I percentiles.
| Extreme phenotype screened, %tile | Number of genetic variants | |||||||
| Total | Exclusively low apoA-I | Exclusively high apoA-I | Both low and high apoA-I | |||||
| NS | S | NS | S | NS | S | P-valuea | ||
| 0–1 | 5 | 3 | 1 | 1 | 0 | 0 | 0 | 0.39 |
| 0–5 | 8 | 4 | 3 | 0 | 0 | 1 | 0 | 0.02 |
| 0–10 | 12 | 4 | 5 | 0 | 0 | 2 | 1 | 0.004 |
| 0–20 | 19 | 8 | 5 | 2 | 1 | 2 | 1 | 0.02 |
| b0–50 | 24 | 7 | 1 | 5 | 1 | 5 | 5 | 0.79 |
a
P-values by Fisher's exact test comparing nonsynonymous (NS) and synonymous (S) variants combined and identified exclusively in the low apoA-I or in the high apoA-I group. Values represent the cumulative number of genetic variants identified in the lowest and highest 0–1 percentile, 0–5 percentile and 0–10 percentile, 0–20 percentile and 0–50 percentile of the apoA-I distribution in the Copenhagen City Heart Study.
b
The upper and lower 0–50 percentiles combined correspond to the total number of nonsynonymous and synonymous variants identified in the Copenhagen City Heart Study.