Figure 2. GBV-C is associated with reduced activation in CD4+ T cell subsets in treated and untreated HIV-infected individuals.

The percentage of naive (A), central memory (CM; B), effector memory (EM; C) and effector (Eff; D) CD4+ T cells expressing CD38 and HLA-DR differed between GBV-C viremic (G+) subjects and those without GBV-C viremia (G-). Results of subjects not receiving combination antiretroviral therapy (HIV viremic positive; HV) or those with suppressed HIV RNA on therapy (HS) and statistical evaluation are provided.