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. 2012 Nov 29;7(11):e50724. doi: 10.1371/journal.pone.0050724

Figure 1. Assessment of spatial learning in the Morris watermaze.

Figure 1

Learning was assessed by the latency in seconds to find the hidden platform. Animals with DS who prenatally received saline (placebo, open circles) did not learn over the 5 day period. Control animals (open squares) who prenatally received saline (placebo) did learn with an approximate halving of their latency. Control animals who prenatally received NAP+SAL (closed squares) also learned over the five day period. Animals with DS who prenatally received NAP+SAL (closed circles) learned over the five day period, similar to controls and significantly better than DS-placebo (p<0.01).