Table 5. Proteome-wide substrate cleavage site predictions at the 100% Specificity level by PROSPER.

Protease	Merops ID	Number of predicted cleavage sites (Human proteome)	Number of predicted cleavage sites (Mouse proteome)
Caspase-1	C14.001	592,172	44,0217
Caspase-3	C14.003	3,339	2,425
Caspase-7	C14.004	22,322	16,590
Caspase-6	C14.005	58,021	43,778
Caspase-8	C14.009	117,891	87,109
Granzyme B (human)	S01.010	127,045	93,043
Granzyme B (mouse)	S01.136	57,149	40,935

This specificity level was used to generate high-confidence prediction results.