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. 2012 Nov 29;7(11):e49295. doi: 10.1371/journal.pone.0049295

Table 4. Blood investigations within 12 hours after admittance in patients with meningococcal disease due to wild-type of lipid A variant strains.

Wild-type Lipid A variant p-valuea
Parameters Median (IQR) N Median (IQR) N
Infectious
White cell count, 109/L (lQR) 15.7 (9.1–23.7) 388 16.4 (13.6–23.1) 28 0.30
Neutrophil count, 109/L (lQR) 12.4 (6.2–20.4) 254 12.8 (8.9–22.4) 17 0.43
-Immature 1.7 (0.58–3.8) 223 1.8 (0.1–2.9) 11 0.50
-Mature 11.0 (4.9–17.2) 261 11.9 (8.3–16.2) 16 0.61
Lymphocyte count, 109/L (lQR) 1.5 (0.9–2.3) 290 1.3 (0.7–2.1) 17 0.40
CRP, mg/dl (lQR) 149 (81–229) 375 126 (75–230) 26 0.48
Coagulation
Thrombocyte count, 109/L (lQR) 216 (163–277) 372 237 (161–282) 25 0.59
PT, sec (IQR) 18 (14–23) 111 13 (2–17) 9 0.01
aPTT, sec (IQR) 40 (33–52) 145 40 (35–57) 8 0.81
Other parameters
Hemoglobine, mmol/l (IQR) 7.5 (6.9–8.3) 383 8.0 (7.3–8.4) 28 0.09
Sodium, mmol/l (IQR) 136 (134–138) 358 136 (133–138) 24 0.49
Potassium, mmol/l (IQR) 3.7 (3.3–4.0) 358 3.9 (3.5–4.2) 23 0.09
Glucose, mmol/l (IQR) 6.9 (5.7–8.3) 322 7.4 (5.7–9.8) 23 0.17
Lactate, µmol/l (IQR) 3.4 (2.2–5.9) 118 2.0 (1.1–2.3) 4 0.03
Creatinine, µmol/l (IQR) 65 (42–97) 327 69 (56–100) 24 0.41
Urea, mmol/l (IQR) 5.3 (4.2–7.3) 305 5.7 (4.1–6.3) 20 0.84

IQR, Interquartile range.

a

P values were calculated by nonparametric tests; all p values are 2 sided.

Clinical manifestations that show a significant correlation (p<0.05) with lipid A variant meningococci are depicted in bold. PT means Prothrombin Time; aPTT is activated Partial Thromboplastin Time.