Table 4. Blood investigations within 12 hours after admittance in patients with meningococcal disease due to wild-type of lipid A variant strains.
Wild-type | Lipid A variant | p-valuea | |||
Parameters | Median (IQR) | N | Median (IQR) | N | |
Infectious | |||||
White cell count, 109/L (lQR) | 15.7 (9.1–23.7) | 388 | 16.4 (13.6–23.1) | 28 | 0.30 |
Neutrophil count, 109/L (lQR) | 12.4 (6.2–20.4) | 254 | 12.8 (8.9–22.4) | 17 | 0.43 |
-Immature | 1.7 (0.58–3.8) | 223 | 1.8 (0.1–2.9) | 11 | 0.50 |
-Mature | 11.0 (4.9–17.2) | 261 | 11.9 (8.3–16.2) | 16 | 0.61 |
Lymphocyte count, 109/L (lQR) | 1.5 (0.9–2.3) | 290 | 1.3 (0.7–2.1) | 17 | 0.40 |
CRP, mg/dl (lQR) | 149 (81–229) | 375 | 126 (75–230) | 26 | 0.48 |
Coagulation | |||||
Thrombocyte count, 109/L (lQR) | 216 (163–277) | 372 | 237 (161–282) | 25 | 0.59 |
PT, sec (IQR) | 18 (14–23) | 111 | 13 (2–17) | 9 | 0.01 |
aPTT, sec (IQR) | 40 (33–52) | 145 | 40 (35–57) | 8 | 0.81 |
Other parameters | |||||
Hemoglobine, mmol/l (IQR) | 7.5 (6.9–8.3) | 383 | 8.0 (7.3–8.4) | 28 | 0.09 |
Sodium, mmol/l (IQR) | 136 (134–138) | 358 | 136 (133–138) | 24 | 0.49 |
Potassium, mmol/l (IQR) | 3.7 (3.3–4.0) | 358 | 3.9 (3.5–4.2) | 23 | 0.09 |
Glucose, mmol/l (IQR) | 6.9 (5.7–8.3) | 322 | 7.4 (5.7–9.8) | 23 | 0.17 |
Lactate, µmol/l (IQR) | 3.4 (2.2–5.9) | 118 | 2.0 (1.1–2.3) | 4 | 0.03 |
Creatinine, µmol/l (IQR) | 65 (42–97) | 327 | 69 (56–100) | 24 | 0.41 |
Urea, mmol/l (IQR) | 5.3 (4.2–7.3) | 305 | 5.7 (4.1–6.3) | 20 | 0.84 |
IQR, Interquartile range.
P values were calculated by nonparametric tests; all p values are 2 sided.
Clinical manifestations that show a significant correlation (p<0.05) with lipid A variant meningococci are depicted in bold. PT means Prothrombin Time; aPTT is activated Partial Thromboplastin Time.