Table 3. IC50 based on Xcelligence measurements of cell proliferation.
Drug/Cell | 17-DMAG | PU-H71 | AUY 922 | BIIB021 | NVP-BEP800 |
L1T2 | 19±3 | 22±8 | 2±0.2 | 29±4 | 93±8 |
KS-KMM | 15±8 | 30±9 | 2±1 | 20±9 | 138±5 |
SLK | 55±2 | 81±10 | 4±2 | 54±5 | 247±29 |
SLK- KSHV | 11±5 | ±0.1 | 0.5±0.2 | 29±3 | 57±12 |
Ratio SLK-KSHV/SLK | 3.3…9.5× | 4.2…5.3× | 2.8…20× | 1.5…2.3× | 3.2…6.2× |
All concentrations are in nM and the result of a titration series with 7 drug concentrations each in n = 2 individual titration experiments. Also shown is the range of ratios for IC50s for SLK compared to isogenic SLK-KSHV cells. This can be interpreted as a selectivity index of KSHV positive compared to KSHV negative cells.