Skip to main content
. 2012 Nov 29;8(11):e1003048. doi: 10.1371/journal.ppat.1003048

Table 3. IC50 based on Xcelligence measurements of cell proliferation.

Drug/Cell 17-DMAG PU-H71 AUY 922 BIIB021 NVP-BEP800
L1T2 19±3 22±8 2±0.2 29±4 93±8
KS-KMM 15±8 30±9 2±1 20±9 138±5
SLK 55±2 81±10 4±2 54±5 247±29
SLK- KSHV 11±5 ±0.1 0.5±0.2 29±3 57±12
Ratio SLK-KSHV/SLK 3.3…9.5× 4.2…5.3× 2.8…20× 1.5…2.3× 3.2…6.2×

All concentrations are in nM and the result of a titration series with 7 drug concentrations each in n = 2 individual titration experiments. Also shown is the range of ratios for IC50s for SLK compared to isogenic SLK-KSHV cells. This can be interpreted as a selectivity index of KSHV positive compared to KSHV negative cells.