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. 2012 Jun 19;18(1):1209–1219. doi: 10.2119/molmed.2012.00083

Figure 4.

Figure 4

RC-3095 attenuated cytokine/chemokine production and cell inflammatory migration in lung of CLP animals. Male Wistar rats were subjected to CLP and were divided (n = 5 per group) into sham-operated, CLP and CLP plus RC-3095 groups. RC- 3095 (3 mg/kg subcutaneously) was administered immediately after surgery. Six hours after surgery, BALF and serum were collected. (A) ELISA showed that RC-3095 attenuated MCP-1 and IL-6 increases induced by CLP in serum (B) and BALF. Results are expressed as means ± SD (*p < 0.05 versus sham and $p < 0.05 versus CLP). (C) Inflammatory cell migration in the BALF was decreased in RC-3095–treated animals. Results are expressed as means ± SD (*p < 0.05 versus saline and $p < 0.05 versus CLP).