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RC-3095 effects were not solely related to the inhibition of TLR-4 signaling. Cells were exposed to TNF-α (Sigma-Aldrich) 4 h later; RC-3095 (10 ng/mL) was added for 2 h. Samples from the medium were collected to determine IL-6 levels. RC-3095 treatment resulted in a significant decrease in IL-6 levels compared with the corresponding levels in TNF-α–stimulated RAW 264.7 (*p < 0.05 versus control and $p < 0.05 versus TNF-α).
