Table 3.

Results from the proportional hazards model examining unique and interactive effects of MDD at T1 and parental/sibling ISUDs on time to develop an ISUD

Variable	HR	95% CI	p-value
Parent Model
T1 MDD	0.91	0.46–1.79	0.78
Parent Illicit Drags	1.10	0.49–2.47	0.82
T1 Cannabis^**	5.31	2.42–11.66	0.00
T1 Alcohol^*	2.43	1.00–5.86	0.05
Intactness of Home^*	0.55	0.32–0.97	0.04
Parent Direct Interview Density	0.86	0.42–1.80	0.69
Gender	1.09	0.68–1.76	0.72
T1 MDD × Parent Illicit Drugs^*	3.18	1.02–9.93	0.05
Sibling Model
T1 MDD	1.50	0.64–3.49	0.35
Sibling Illicit Drugs	1.95	0.80–4.77	0.14
T1 Cannabis	2.45	0.62–9.74	0.20
T1 Alcohol^**	4.49	1.52–16.01	0.01
Intactness of Home	0.88	0.45–1.72	0.71
Sibling Direct Interview Density	0.55	0.24–1.23	0.14
Gender	1.72	0.93–3.19	0.09
T1 MDD × Sibling Illicit Drugs	1.50	0.40–5.73	0.55

Note.

^**

p < .05.

Parent Illicit Drugs = parental history of ISUDs dichotomized as no lifetime diagnosis of an ISUD or history of any ISUD (in either parent); Sibling Illicit Drugs = sibling history of ISUDs dichotomized as no lifetime diagnosis of an ISUD or history of any ISUD (in any sibling); T1 MDD, T1 Cannabis, and T1 Alcohol = lifetime diagnosis at the T1 assessment.