Table 4.

Results from the proportional hazards models examining the unique risk associated with parental and sibling history of ISUDs

Variable	HR	95% CI	p-value
Block One
Sibling Illicit Drugs	1.15	0.60–2.20	0.68
Parent Illicit Drugs*	1.79	1.01–3.18	0.05
Block Two
T1 MDD	0.91	0.46–1.80	0.78
Sibling Illicit Drugs	1.24	0.65–2.38	0.51
Parent Illicit Drugs	1.09	0.48–2.46	0.84
T1 Cannabis**	5.39	2.50–11.63	0.00
T1 Alcohol*	2.47	1.03–5.90	0.04
Intactness of Home*	0.56	0.32–0.98	0.04
Parent Direct Interview Density	0.83	0.39–1.74	0.62
Sibling Direct Interview Density	1.7	0.54–2.13	0.84
Gender	1.09	0.67–1.76	0.73
T1 MDD × Parent Illicit Drugs*	3.09	0.99–9.64	0.05

Note.

^**p < .01;

^*p < .05.

Parent Illicit Drugs = parental history of ISUDs dichotomized as no lifetime diagnosis of an ISUD or history of any ISUD (in either parent); Sibling Illicit Drugs = sibling history of ISUDs dichotomized as no lifetime diagnosis of an ISUD or history of any ISUD (in any sibling); T1 MDD, T1 Cannabis, and T1 Alcohol = lifetime diagnosis at the T1 assessment.