Table 1.
Impact of ketamine infusion on sleep (n=30)
| Variables | BSL (1) Mean(±s.e.m.) |
Infusion (2) Mean (±s.e.m.) |
Recovery (3) Mean (±s.e.m.) |
ANOVA |
p value for comparison a |
||||
|---|---|---|---|---|---|---|---|---|---|
| df | F | p | 1 vs.2 | 2 vs.3 | 1 vs. 3 | ||||
| TST, min | 368.10 (10.4) | 392.97 (7.63) | 395.00 (8.35) | 2, 58 | 5.5 | <0.01 | 0.02 | 1.00 | 0.01 |
| S1, % | 9.46 (0.93) | 7.79 (0.71) | 8.84 (0.81) | 2, 58 | 3.3 | <0.05 | 0.03 | 0.33 | 1.00 |
| S2, % | 62.11(1.80) | 58.32 (2.14) | 59.63 (1.98) | 2, 58 | 4.74 | 0.01 | 0.001 | 0.14 | 0.87 |
| SWS, % | 3.52 (0.70) | 4.73 (0.99) | 4.40 (0.92) | 2, 58 | 16.6 | 0.01 | 0.04 | 1.00 | 0.20 |
| REM, % | 25.28 (1.30) | 29.51 (1.59) | 27.72 (1.28) | 2, 58 | 5.9 | <0.01 | 0.001 | 0.38 | 0.11 |
| SOL, min | 24.11 (3.7) | 15.56 (2.26) | 18.23 (3.1) | 2, 58 | 4.1 | <0.05 | 0.01 | 1.00 | 0.13 |
| REML, min | 78.71 (6.9) | 61.23 (6.6) | 66.71 (6.5) | 2, 58 | 4.6 | 0.01 | 0.01 | 1.00 | 0.13 |
| Waking, % rec | 17.37 (2.16) | 13.48 (1.43) | 13.25 (1.61) | 2, 58 | 3.5 | <0.05 | 0.06 | 1.00 | 0.04 |
BSL, Baseline; ANOVA, analysis of variance ; TST, total sleep time; S1, non-rapid eye movement (NREM) stage 1 (% of TST); S2, NREM stage 2 (% of TST); SWS, slow wave sleep ; REM, stage REM (% of TST); SOL, sleep onset latency ; REML, REM sleep latency ; rec, recording time.
a
Post-hoc t tests. p values are expressed with Bonferroni’s correction where p<0.05 is considered significant.