Table 4.
Multivariable adjusted* odds ratio (OR) (95% confidence interval) for Parkinson’s Disease by quintile (Q) of PCB concentration (ng/g serum).
Congener | Q1 | Q2 | Q3 | Q4 | Q5 | p-trend |
---|---|---|---|---|---|---|
PCB 118, range† (ng/g serum) | <0.234 | 0.234–0.287 | 0.288–0.360 | 0.361–0.460 | 0.460–1.387 | |
Unconditional model# | Ref | 0.54 (0.26–1.12) | 0.64 (0.30–1.36) | 0.68 (0.31–1.46) | 0.37 (0.14–0.95) | 0.10 |
Conditional model$ | Ref | 0.73 (0.32–1.63) | 0.76 (0.33–1.75) | 0.65 (0.28–1.52) | 0.38 (0.12–1.25) | 0.13 |
| ||||||
PCB 138, range† (ng/g serum) | <0.488 | 0.489–0.631 | 0.632–0.820 | 0.829–1.157 | 1.157–3.630 | |
Unconditional model# | Ref | 0.80 (0.38–1.66) | 0.66 (0.30–1.45) | 0.56 (0.23–1.35) | 0.43 (0.16–1.14) | 0.09 |
Conditional model$ | Ref | 0.86 (0.36–2.04) | 0.64 (0.26–1.61) | 0.61 (0.22–1.67) | 0.41 (0.12–1.42) | 0.16 |
| ||||||
PCB 153, range† (ng/g serum) | <0.768 | 0.769–1.016 | 1.020–1.346 | 1.347–1.882 | 1.884–5.211 | |
Unconditional model# | Ref | 0.79 (0.38–1.65) | 0.67 (0.31–1.49) | 0.66 (0.28–1.56) | 0.36 (0.13–1.00) | 0.06 |
Conditional model$ | Ref | 0.72 (0.29–1.78) | 0.66 (0.26–1.64) | 0.65 (0.23–1.87) | 0.28 (0.07–1.07) | 0.08 |
| ||||||
PCB 180, range† (ng/g serum) | <0.436 | 0.436–0.620 | 0.620–0.813 | 0.813–1.133 | 1.137–3.071 | |
Unconditional model# | Ref | 1.05 (0.50–2.23) | 0.81 (0.34–1.89) | 0.46 (0.18–1.22) | 0.53 (0.19–1.53) | 0.12 |
Conditional model$ | Ref | 1.53 (0.60–3.91) | 1.24 (0.44–3.53) | 0.58 (0.19–1.78) | 0.65 (0.17–2.43) | 0.17 |
| ||||||
Sum of Dioxin-like congeners, range† (ng/g serum) | <0.404 | 0.405–0.516 | 0.516–0.641 | 0.645–0.829 | 0.831–2.228 | |
Unconditional model# | Ref | 0.68 (0.34–1.38) | 0.63 (0.30–1.33) | 0.65 (0.29–1.45) | 0.34 (0.13–0.90) | 0.05 |
Conditional model$ | Ref | 0.85 (0.39–1.83) | 0.60 (0.27–1.36) | 0.62 (0.25–1.52) | 0.32 (0.10–1.05) | 0.04 |
| ||||||
Total PCBs, range† (ng/g serum) | <4.56 | 4.56–5.79 | 5.81–7.46 | 7.49–10.00 | 10.01–82.10 | |
Unconditional model# | Ref | 0.45 (0.22–0.94) | 0.50 (0.23–1.08) | 0.54 (0.24–1.21) | 0.29 (0.12–0.70) | 0.02 |
Conditional model$ | Ref | 0.43 (0.17–1.08) | 0.53 (0.21–1.29) | 0.53 (0.19–1.46) | 0.28 (0.09–0.90) | 0.08 |
Adjusting for matching factors age, sex, and region (by stratification in the conditional logistic model), as well as smoking, BMI, triglycerides, cholesterol, occupation, and serum dieldrin concentration.
Among 101 cases and 349 controls.
101 cases, 349 controls.
101 cases, 186 controls.