Skip to main content
. Author manuscript; available in PMC: 2013 Jun 1.
Published in final edited form as: Nat Genet. 2012 Nov 11;44(12):1349–1354. doi: 10.1038/ng.2466

Table 3.

Allele frequencies for rs10273639 (risk allele C) and rs12688220 (risk allele T) when data are stratified by controls or pancreatitis ± alcohol-related diagnosis.

Status Alcohol-related Number of individuals rs102736391 (C) frequency rs126882201 (T) frequency
Control -- 8029 0.576 0.261
Pancreatitis No 1129 0.634 0.322
Yes 447 0.696 0.427
1

Using data from cases only and in a joint analysis of both SNPs, rs12688220 predicts alcohol-related pancreatitis as genotypes (χ2=29.57; DF=2; p-value = 4×10-7) or count of risk alleles (χ2=13.17; DF=1; p-value = 3×10-4). rs10273639 (PRSS1-PRSS2 locus) is a significant predictor (count of risk alleles: χ2=5.68; DF=1; p-value = 0.017; genotypes: χ2=6.05; DF=2; p-value = 0.049), even after accounting for the effects of rs12688220.