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. 2012 Nov 30;3:355. doi: 10.3389/fimmu.2012.00355

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Copyright © 2012 Zinöcker, Dressel, Wang, Dickinson and Rolstad.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.

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Schematic outline of the transplantation protocol applied in the MHC mismatched rat model. (A) BN rats served as recipients and PVG.7B rats as bone marrow and lymph node donors for bone marrow transplantation (BMT) and donor lymphocyte infusion (DLI), respectively, in fully MHC-incompatible alloHCT performed as shown in (B). Recipient rats were lethally irradiated (900 cGy), rescued by an intravenous injection of donor bone marrow cells and 14 days later received a graded dose of donor lymph node cells to invoke fatal GvHD. Controls received sham treatment (injection without cells) instead of DLI. Blood samples were collected in weekly intervals from the day of DLI for subsequent analysis of reconstitution and chimerism.