Figure 2.

Histopathology of GvHD in rats transplanted with allogeneic, fully MHC mismatched bone marrow. Grade II (A) and III–IV (B) pathology is manifest in the skin of BN rats that suffered from acute GvHD after bone marrow transplantation and donor lymphocyte infusion from PVG donors. Pathological grading was performed based on the GvHD classification originally described by Lerner et al. (1974) for human skin GvHD. Skin was removed from the paws at autopsy and tissue sections were stained with hematoxylin and eosin. These photographs are reprinted from Novota et al. (2008) with permission from the publisher.