Figure 3.

Comparison of the histopathology of GvHR in human skin explants and rat skin explants. GvHR of increasing severity occur during co-incubation of pre-stimulated, allogeneic lymphocytes with explants of rat skin (A–D) or human skin biopsies (E–H). Grade I [mild vacuolization of epidermal cells with occasional dyskeratotic bodies; (A,E)], grade II [diffuse vacuolization of basal cells with scattered dyskeratotic bodies; (B,F)], grade III [formation of subepidermal clefts; (C,G)], and grade IV [complete separation of the epidermis from the dermis; (D,H)] pathological changes are similar in human and rat skin explants. The photographs of the rat skin explants depicted in (A–D) were reprinted from Novota et al. (2008) with permission from the publisher.