Table 1.

Values of the biological parameters used into our model equations

Variable	Description	Value	References
C (M)	Maximum tumor cell density	106 cell/cm2	Rockne et al. (2010)
\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$O_{2}^{(S)}$\end{document}	Oxygen concentration switch to hypoxia	7 mmHg	Vaupel (2004)
\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$O_{2}^{(T)}$\end{document}	Michaelis Menten oxygen threshold	2.5 mmHg	Daçu et al. (2003)
\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$O_{2}^{(D)}$\end{document}	Oxygen level for anoxia	0.7 mmHg	Brown and Wilson (2004)
\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$O_{2}^{v_{i}},{i=1,2}$\end{document}	Vessel oxygen concentration	60 mmHg	Wilson (2008) Kimura et al. (1996)
α n	Normoxic cell oxygen consumption	10−17 Mol/(c s)	Griguer et al. (2008)
α h	Hypoxic cell oxygen consumption	α n/5 Mol/(c s)	Griguer et al. (2008)
D n	Diffusion coefficient for normoxic cells	6.6⋅10−12 cm2/s	Tjia and Moghe (2002) Wang et al. (2009)
D h	Diffusion coefficient for hypoxic cells	10 D n cm2/s	Tjia and Moghe (2002) Wang et al. (2009)
\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$D_{O_{2}}$\end{document}	Oxygen diffusion coefficient	10−5 cm2/s	Mueller-Klieser and Sutherland (1984)
τ nh	Phenotype switch time (normoxic to hypoxic)	1 h	Jewell and Gassmann (2001)
τ hn	Phenotype switch time (hypoxic to normoxic)	96 h	Estimated
τ hd	Cell death mean time in anoxia	48 h	Estimated
τ n	Normoxic cell doubling time	24 h	Ke et al. (2000)
τ h	Hypoxic cell doubling time	48 h	Giese et al. (2003) Berens and Giese (1999)
ΔO 2	Sensitivity around transition threshold	0.1 Mol/mm3	Estimated
J	Oxygen exchange coefficient	0.1 cm	Mazumdar (1992)