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. 2012 Sep 21;40(21):10657–10667. doi: 10.1093/nar/gks860

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© The Author(s) 2012. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — Schematic illustrations of network inference approaches. Dynamic approach (upper block) can reconstruct the dynamic network to describe the dynamic behaviours of transcriptional regulation by using time-course data, which is normally not available for many bio-medical problems; static approach (middle block) reconstruct static network which can only describe the (pooled average) static behaviours of transcriptional regulation by using sample-based data; our DCM (lower block) is able to reconstruct the dynamic network which describe the dynamic gene regulation even by using the sample-based data.