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. 2012 Sep 21;40(21):10657–10667. doi: 10.1093/nar/gks860

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© The Author(s) 2012. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — Results of the performance test on in silico network of the simulation study. (A) Result of sensitivity test on different settings of the inter-stage influence coefficient. The overall AUCs were generally >0.7 for most of settings. In particular, the overall AUC reached the peak value of 0.76 when was set to a value between 0.5 and 0.65. (B) Result of sensitivity test on different settings for number of samples in a bootstrap group. The overall AUCs were above 0.75 when the number of samples in a bootstrapping group was set in the range from 8 to 18 (recall that the number of samples for stage I, II, III and IV are 20, 30, 20 and 30, respectively). (C) Result of robustness test on different levels of noise corruption to the transcriptional data. The overall AUCs were over 0.73 when the noise-to-signal level was smaller than 0.15. When the noise level increased to 0.2–0.3, the overall AUC gradually dropped to 0.67. It further dropped to 0.62 when the noise level increased to 0.4, and eventually became unacceptable (∼0.55) when the noise level reached 0.5.

Inline graphic — Results of the performance test on in silico network of the simulation study. (A) Result of sensitivity test on different settings of the inter-stage influence coefficient. The overall AUCs were generally >0.7 for most of settings. In particular, the overall AUC reached the peak value of 0.76 when was set to a value between 0.5 and 0.65. (B) Result of sensitivity test on different settings for number of samples in a bootstrap group. The overall AUCs were above 0.75 when the number of samples in a bootstrapping group was set in the range from 8 to 18 (recall that the number of samples for stage I, II, III and IV are 20, 30, 20 and 30, respectively). (C) Result of robustness test on different levels of noise corruption to the transcriptional data. The overall AUCs were over 0.73 when the noise-to-signal level was smaller than 0.15. When the noise level increased to 0.2–0.3, the overall AUC gradually dropped to 0.67. It further dropped to 0.62 when the noise level increased to 0.4, and eventually became unacceptable (∼0.55) when the noise level reached 0.5.