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. 2012 Sep 12;40(21):10679–10688. doi: 10.1093/nar/gks855

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© The Author(s) 2012. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — CDC6 3′-UTR (1160 nucleotides) and the positions of the probes are shown. Nine of the probes matched to the site upstream of the proximal poly(A) (P-pA) site and two of the probes matched to the region between P-pA and distal poly(A) (D-pA) site. P-pA and D-pA are the reported poly(A) sites (16). Three independent gene expression datasets for E2 treatment in MCF7 cells (GSE8597, GSE11791, GSE11324) were analysed at the probe level. The mean of nine proximal and two distal probe set signals were collected. The proximal to distal signal ratio in E2-treated (R_E2) MCF7 cells increased at least 1.5× fold compared with the ratios (R_C) of the control cells.