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Role of PGC-1α/β in NCoR1 regulation of oxidative metabolism. (A) Gastrocnemius (GAS) mRNA levels of the PGC-1 family of coactivators (n = 7 CON and n = 5 NCoR1 MKO mice). (B to D) Adenoviral knockdown (KD) of LacZ (CON) or NCoR1 alone or in combination with PGC-1α or PGC-1β KD for 48 h in C2C12 myotubes (n = 3 independent experiments each performed in triplicate). Values represent means ± SEM. P < 0.05 (*), P < 0.01 (**), and P < 0.001 (***) for CON versus MKO mice or as indicated.
